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	Provedor de dados BJMBR (2) Autor Biselli,P.J.C. (1) Lopes,F.D.T.Q.S. (1) Lucetti,L.T. (1) Magalhães,P.J.C. (1) Martins,M.A. (1) Mauad,T. (1) Moriya,H.T. (1) Ribeiro-Filho,H.V. (1) Rivero,D.H.R.F. (1) Saldiva,P.H.N. (1) Toledo,A.C. (1) Vasconcelos,T.B. (1) Mais... Palavra-chave Airways (2) Calcium channels (1) Cigarette smoke (1) Emphysema (1) Monoterpenes (1) Mouse airway epithelium remodeling (1) Proximal airspace enlargements (1) Smooth muscle (1) TGF-β1 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling BJMBR Biselli,P.J.C.; Lopes,F.D.T.Q.S.; Moriya,H.T.; Rivero,D.H.R.F.; Toledo,A.C.; Saldiva,P.H.N.; Mauad,T.; Martins,M.A.. Chronic obstructive pulmonary disease (COPD) is associated with inflammatory cell reactions, tissue destruction and lung remodeling. Many signaling pathways for these phenomena are still to be identified. We developed a mouse model of COPD to evaluate some pathophysiological mechanisms acting during the initial stage of the disease. Forty-seven 6- to 8-week-old female C57/BL6 mice (approximately 22 g) were exposed for 2 months to cigarette smoke and/or residual oil fly ash (ROFA), a concentrate of air pollution. We measured lung mechanics, airspace enlargement, airway wall thickness, epithelial cell profile, elastic and collagen fiber deposition, and by immunohistochemistry transforming growth factor-β1 (TGF-β1), macrophage elastase (MMP12), neutrophils... Tipo: Info:eu-repo/semantics/article Palavras-chave: Emphysema; Cigarette smoke; Airways; TGF-β1; Mouse airway epithelium remodeling; Proximal airspace enlargements. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000500012 β-Citronellol, an alcoholic monoterpene with inhibitory properties on the contractility of rat trachea BJMBR Vasconcelos,T.B.; Ribeiro-Filho,H.V.; Lucetti,L.T.; Magalhães,P.J.C.. β-Citronellol is an alcoholic monoterpene found in essential oils such Cymbopogon citratus (a plant with antihypertensive properties). β-Citronellol can act against pathogenic microorganisms that affect airways and, in virtue of the popular use of β-citronellol-enriched essential oils in aromatherapy, we assessed its pharmacologic effects on the contractility of rat trachea. Contractions of isolated tracheal rings were recorded isometrically through a force transducer connected to a data-acquisition device. β-Citronellol relaxed sustained contractions induced by acetylcholine or high extracellular potassium, but half-maximal inhibitory concentrations (IC50) for K+-elicited stimuli were smaller than those for cholinergic contractions. It also inhibited... Tipo: Info:eu-repo/semantics/article Palavras-chave: Monoterpenes; Calcium channels; Smooth muscle; Airways. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200605 Registros recuperados: 2 Primeira ... 1 ... Última

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